CGRP antibodies for the prevention of migraines

Have you heard the news about the new, recently approved CGRP treatments for the prevention of Migraine? Here, we will try and cover some information about these exciting new treatment options for Migraine.

Q: What are CGRP antibodies?

A: This new drug class for the preventative treatment of Migraine started its development almost 10 years ago. As of October 2018, three antibodies that target an inflammatory protein which can trigger migraine attacks have been approved by the FDA for the treatment of Episodic and Chronic Migraine. This protein is called Calcitonin-Gene Related Peptide (CGRP). Clinvest has been involved over the last few years in many of the clinical trials which led to approval for all three products: AimovigTM made by Amgen, AjvoyTM by Teva, and EmgalityTM by Eli Lilly. There are also several more medications in this class in the development process and on the way to approval.  

Q: How do I take these medications?

A: All three of the currently approved treatments are available as an injection administered subcutaneously. AimovigTM and EmgalityTM are typically given once a month by injection to the arm, leg or abdomen. While AjovyTM can be administered either monthly or quarterly. Both AimovigTM and AjovyTM had two approved doses. Many times, your first injection will be done in the doctor’s office or with a nurse at home. After that, many people choose to do these injections at home without any assistance. If you want to learn more about these treatments it is best to talk with your provider.

Q: What is the cost of CGRP medications and does my insurance cover them?

A: While none of the new CGRP treatments are cheap and can cost almost $600 a month retail, all three of the manufacturers offer ways to receive their products at highly discounted prices. Often the discounted prices as little as $5 a month or even free. So, don’t forget to ask your provider about assistance programs that might be available to reduce your cost.

Q: What is the future of CGRP treatments for Migraine?

A: Surprisingly, there are even more CGRP treatments on the horizon which include Alder Biopharmaceuticals, Allergan, and Biohaven. These treatments focus on different delivery systems including IV and oral administration and will hopefully get approved in the near future as well.

Q: Do you want to learn more about CGRP antibodies for the prevention of migraine?

A: We are very excited to be able to provide these treatments for patients at Headache Management of Springfield and are taking new patient appointments with quick availability.  

Give us a call today to schedule an appointment with Certified Headache Specialist, Dr. Carol Matthews, DNP to talk about treatment options. 417-883-7889