Active Headache & Migraine Studies

We are constantly seeking participants for a number of studies. Please apply to any studies for which you may qualify, or call us at (417) 883-7889 for more information!

If You Suffer from Migraines, Clinvest Is Here to Help

The piercing sensation from a headache or migraine can be debilitating. Our goal is to research and collect data on new medications that may be life-changing to this painful condition. We conduct a variety of headache and migraine studies with specific study topics ranging from chronic migraine prevention to post-traumatic headaches.

Clinvest knows how challenging and frustrating head pain can be. We have a strong commitment to further treatment and research in migraine studies. We partner with pharmaceutical companies in an effort to discover solutions for such debilitating conditions and look forward to the new horizons in health and well-being.

    Episodic Migraine Research Study

    Allergan 3101

    Dr. True and Clinvest are seeking volunteers with Prodrome prior to Episodic Migraines in the Springfield area. The overall study objective is to evaluate the efficacy, safety, and tolerability of ubrogepant 100mg compared to placebo for the acute treatment of migraine during prodrome. Participants will be randomized (1:1) to treatment sequences A or B in this crossover study. Completion of the study would involve coming into the office for 4 appointments and 1 phone call over approximately a 4-month period. Your first appointment would last approximately 2 hours. You will be asked to come into the office for 2 visits that will occur up to 60 days after initial screening. If you qualify and choose to volunteer, we would provide the study drug and all study-related procedures at no cost to you (including basic study-related physical exams, bloodwork, ECG’s, and urine drug/pregnancy tests). Compensation will be provided for your time and travel.

    Duration: 4 Months


    Number: 4 Visits

    Migraine Research Study

    BHV3500-301

    The purpose of this research study is to compare the duration, safety, and effectiveness of a study medication to treat one migraine attack. Qualified volunteers will be randomly assigned to receive study medication or Placebo. Completion of the study would involve coming into the office for 3 appointments over an approximately 11-week period. Your first appointment would last approximately 2 hours. You will be asked to come into the office between 3 – 28 days following screening and then within 45 days for an approximate duration of 11-weeks. If you qualify and choose to volunteer, we would provide study drug and all study-related procedures at no cost to you (including basic study-related physical exams, bloodwork, ECG’s, and urine drug/pregnancy tests). You would be asked to use a handheld electronic diary to answer daily questions about your headaches for the entire duration of the study. You would also be asked to fill out more detailed questionnaires during the appointments. Compensation will be provided for your time and travel.

    Duration: 11 Weeks


    Number: 3 Visits

    Migraine Research Study

    ST101-003

    The purpose of this research study is to compare the duration, safety, and effectiveness of the study medication STS101 (DHE nasal powder) to use on an as needed basis to treat migraine attacks.  Qualified volunteers will be assigned study medication and use up to 2 doses for treatment of a single migraine attack within 24 hours. Completion of the study would involve coming into the office for 11 appointments over an approximately 13-month period. Your first appointment would last approximately 2 hours. You will be asked to come into the office between 28 – 30 days following screening and then monthly for an approximate duration of 13-months.  If you qualify and choose to volunteer, we would provide study drug and all study-related procedures at no cost to you (including basic study-related physical exams, bloodwork, ECG’s, and urine drug/pregnancy tests). You would be asked to use a handheld electronic diary to answer daily questions about your headaches for the entire duration of the study. You would also be asked to fill out more detailed questionnaires during the appointments. Compensation will be provided for your time and travel. 

    Duration: 13 Months


    Number: 11 Visits

    Adolescent Migraine Research Study

    LAHV

    This is a randomized, double-blind trial to assess the safety and effectiveness of Lasmiditan for children and adolescents age 6 to 17 with migraine. The study will address one qualifying migraine with the option of then entering a second, year long trial. If you qualify and choose to volunteer, study drug and all study-related procedures would be provided at no cost to you (including basic study-related physical exams, lab work, ECG’s, and lifestyle advice). During the study, you would be asked to use a diary at home to record information and you will be asked to fill out more detailed questionnaires during study appointments. Compensation will be provided for your time and travel. This study consists on a minimum of 3 visits. The first visit will take around 2 hours. After eligibility is confirmed the subject will be asked to return to the clinic for instructions on the use of the study medication. Once a qualifying migraine has been treated, a final visit will be scheduled. During that final visit you may be asked if you would like to participate in an open label year long study.

    Duration: Up to 1 Year


    Number: 3+ Visits

    Migraine Research Study

    BHV3500-202

    The purpose of this research study is to assess the safety and tolerability of intranasal (IN) administration of vazegepant in subjects with migraine. Subjects will be allowed to treat up to 8 migraine attacks per month, for up to 1 year. This study will consist of a screening visit, 28-day observation period, pre baseline visit, baseline visit, 2-week follow-up and monthly follow-up visits thereafter. Participation in the study is expected to last 52 weeks, which includes 18 clinic visits. Your first appointment will last approximately 2 hours. The study medication and all study-related procedures are provided to eligible participants at no cost (including basic study-related physical exams, ECG’s and lab tests). Compensation up to $1350 ($75/visit) may be provided for your time and travel.

    Duration: 1 Year


    Number: 18

    High Frequency Migraine Research Study

    AMGEN-2019008

    This is a trial to assess the effect of an investigational drug on subjects with high frequency episodic migraine who have previously failed 1 or more migraine preventive treatments. If you qualify and choose to volunteer, study drug, and all study-related procedures would be provided at no cost to you. During the study, you would be asked to use an electronic diary at home to record headache information. This study has 8 visits over approximately 25 weeks. Reasonable reimbursement will be provided for travel and parking for each visit you complete.

    Duration: over approximately 25 weeks


    Number: 8 visits

    Migraine Research Study

    AMGEN-2018060

    This is a trial to assess the effect of an investigational medication on disability and work productivity in employed subjects with episodic migraine who have previously failed 1 or more migraine preventive treatments. The study has 9 visits over approximately 31 weeks. Compensation for time and travel is up to $450.

    Duration: over approximately 31 weeks


    Number: 9 visits

Want to find out when new studies are available?

Fill out the form!