Active Headache & Migraine Studies

We are constantly seeking participants for a number of studies. Please apply to any studies for which you may qualify, or call us at (417) 883-7889 for more information!

If You Suffer from Migraines, Clinvest Is Here to Help

The piercing sensation from a headache or migraine can be debilitating. Our goal is to research and collect data on new medications that may be life-changing to this painful condition. We conduct a variety of headache and migraine studies with specific study topics ranging from chronic migraine prevention to post-traumatic headaches.

Clinvest knows how challenging and frustrating head pain can be. We have a strong commitment to further treatment and research in migraine studies. We partner with pharmaceutical companies in an effort to discover solutions for such debilitating conditions and look forward to the new horizons in health and well-being.

    Migraine Preventative Device Study

    TCH-008

    Dr. True and Clinvest are seeking volunteers with migraines in the Springfield area. The purpose of this research study is to evaluate the effectiveness of the study device Nerivio for migraine prevention. Qualified volunteers will be randomly assigned to an active or sham study group. The study will consist of 4 visits over an approximate 16-week period. Your first appointment would last approximately 2 hours. Upon successful completion of the treatment phase, if eligible, you can elect to enter a 4-week open label phase. If you qualify and choose to volunteer, we would provide the study device and all study-related procedures at no cost to you (including training, medical history review, urine, drug and pregnancy tests). Compensation may be provided for your time and travel.

    Duration: 16 Weeks


    Number: 4 Visits

    Episodic Migraine Research Study

    Allergan 3101-304-002

    The purpose of this research study is to assess the safety, tolerability, and efficacy of Atogepant compared to placebo for the prevention of migraine in participants who previously failed oral preventative medications. There will be 8 scheduled clinic visits. The double-blind treatment period will last 12 weeks, with a safety follow-up period of 4 additional weeks. Participants will be given the option to roll over into a long-term safety extension study. For these rollover participants the follow-up visit will be performed in the long-term safety extension study. If you qualify and choose to volunteer, we would provide the investigational study drug, as well as all study-related procedures at no cost to you (including basic study-related physical exams, bloodwork, ECG’s, and urine drug/pregnancy tests). You may be compensated for your time and effort. Total duration of study participation for one participant is approximately 20 weeks.

    Duration: 20 Weeks


    Number: 8 Visits

    Episodic Migraine Device Research Study

    Vorso 2020-12

    The purpose of this research study is to evaluate the safety and effectiveness of Vorso’s device for the prevention of migraine. Qualified volunteers will be randomly assigned to the active device or sham stimulation 15 minutes a day. If you qualify and choose to volunteer, we would provide the study device and eDiary, as well as all study-related procedures at no cost to you (including basic study-related physical exams, bloodwork, ECG’s, and urine drug/pregnancy tests). You may be compensated for your time and effort. This is a 7-month study with 9 in office visits and monthly phone call visits.

    Duration: 7 Months


    Number: 9 Visits

    Treatment-Resistant Migraine Research Study

    J1H-MC-LAJB

    The purpose of this research study is to assess the study medication LY3451838 in subjects with treatment-resistant migraine. The study is placebo controlled, with a 1 to 1 ratio, and is administered through a single dose IV infusion. Completion of the study would involve coming into the office for 11 visits over a 24-week period. Your first appointment would last 2-3 hours and the day of IV infusion will last approximately 8 hours. All other visits will last about 1 hour. If you qualify and choose to volunteer, we would provide the study drug and all study-related procedures at no cost to you (including basic study-related physical exams, bloodwork, ECG’s and urine drug or pregnancy tests). You would be asked to complete detailed questionnaires about your symptoms during appointments and complete a daily diary for the duration of the study. Compensation will be provided for your time.

    Duration: 24 Weeks


    Number: 11 Visits

    Episodic Migraine Research Study

    Allergan 3101

    The purpose of this research study is to evaluate treatment effectiveness and safety, in participants with episodic cluster headaches. Participants will come to the clinic for an initial screening visit that may take 2-3 hours. Participants will have up to 52 weeks to report a cluster bout to the study team. The subject will then return to the clinic to begin tracking their attacks with an electronic diary for 7 days. They will then come to the clinic on 2 separate occasions for an IV infusion of the study drug. Following the treatment period, subject will remain under the observation of the study team for 20 weeks. This study will consist of 6 in-office visits and 4 phone calls.

    Duration: Up To 72 Weeks


    Number: 6 Visits

    Episodic Migraine Research Study

    Allergan 3110

    Dr. True and Clinvest are seeking volunteers with Prodrome prior to Episodic Migraines in the Springfield area. The overall study objective is to evaluate the efficacy, safety, and tolerability of ubrogepant 100mg compared to placebo for the acute treatment of migraine during prodrome. Participants will be randomized (1:1) to treatment sequences A or B in this crossover study. Completion of the study would involve coming into the office for 4 appointments and 1 phone call over approximately a 4-month period. Your first appointment would last approximately 2 hours. You will be asked to come into the office for 2 visits that will occur up to 60 days after initial screening. If you qualify and choose to volunteer, we would provide the study drug and all study-related procedures at no cost to you (including basic study-related physical exams, bloodwork, ECG’s, and urine drug/pregnancy tests). Compensation will be provided for your time and travel.

    Duration: 4 Months


    Number: 4 Visits

    Migraine Research Study

    BHV3500-301

    The purpose of this research study is to compare the duration, safety, and effectiveness of a study medication to treat one migraine attack. Qualified volunteers will be randomly assigned to receive study medication or Placebo. Completion of the study would involve coming into the office for 3 appointments over an approximately 11-week period. Your first appointment would last approximately 2 hours. You will be asked to come into the office between 3 – 28 days following screening and then within 45 days for an approximate duration of 11-weeks. If you qualify and choose to volunteer, we would provide study drug and all study-related procedures at no cost to you (including basic study-related physical exams, bloodwork, ECG’s, and urine drug/pregnancy tests). You would be asked to use a handheld electronic diary to answer daily questions about your headaches for the entire duration of the study. You would also be asked to fill out more detailed questionnaires during the appointments. Compensation will be provided for your time and travel.

    Duration: 11 Weeks


    Number: 3 Visits

    Adolescent Migraine Research Study

    LAHV

    This is a randomized, double-blind trial to assess the safety and effectiveness of Lasmiditan for children and adolescents age 6 to 17 with migraine. The study will address one qualifying migraine with the option of then entering a second, year long trial. If you qualify and choose to volunteer, study drug and all study-related procedures would be provided at no cost to you (including basic study-related physical exams, lab work, ECG’s, and lifestyle advice). During the study, you would be asked to use a diary at home to record information and you will be asked to fill out more detailed questionnaires during study appointments. Compensation will be provided for your time and travel. This study consists on a minimum of 3 visits. The first visit will take around 2 hours. After eligibility is confirmed the subject will be asked to return to the clinic for instructions on the use of the study medication. Once a qualifying migraine has been treated, a final visit will be scheduled. During that final visit you may be asked if you would like to participate in an open label year long study.

    Duration: Up to 1 Year


    Number: 3+ Visits

    High Frequency Migraine Research Study

    AMGEN-2019008

    This is a trial to assess the effect of an investigational drug on subjects with high frequency episodic migraine who have previously failed 1 or more migraine preventive treatments. If you qualify and choose to volunteer, study drug, and all study-related procedures would be provided at no cost to you. During the study, you would be asked to use an electronic diary at home to record headache information. This study has 8 visits over approximately 25 weeks. Reasonable reimbursement will be provided for travel and parking for each visit you complete.

    Duration: over approximately 25 weeks


    Number: 8 visits

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