Active Headache & Migraine Studies

We are constantly seeking participants for a number of studies. Please apply to any studies for which you may qualify, or call us at (417) 883-7889 for more information!

If You Suffer from Migraines, Clinvest Is Here to Help

The piercing sensation from a headache or migraine can be debilitating. Our goal is to research and collect data on new medications that may be life-changing to this painful condition. We conduct a variety of headache and migraine studies with specific study topics ranging from chronic migraine prevention to post-traumatic headaches.

Clinvest knows how challenging and frustrating head pain can be. We have a strong commitment to further treatment and research in migraine studies. We partner with pharmaceutical companies in an effort to discover solutions for such debilitating conditions and look forward to the new horizons in health and well-being.

    Migraine Research Study

    Alder-015

    Dr. True and Clinvest are seeking volunteers with migraine. This study evaluates the effectiveness of the study drug during a migraine attack. Qualified volunteers will be randomly assigned to receive a study drug or a matching placebo. The total duration of the study will last up to approximately 12 weeks and up to three clinic visits. Your first appointment will last approximately two hours. Once you experience a qualifying migraine, you will come in for your second appointment within six hours after the start of the migraine. This visit will last approximately six hours. The study drug will be administered by IV. Study drug and all study-related procedures will be provided at no cost to you (including basic study-related physical exams, bloodwork, ECG’s, and urine drug/pregnancy tests). Compensation will be provided for qualified participants.

    Duration: 12 Weeks

    Number: 3

    Migraine Device Study

    TCH-006

    This study is a chronic migraine study for ages 18-75 using a neuromodulator device on your upper arm. This device will sync via Bluetooth to a smartphone, which will control the device, as well as the location of headache diary. A total of up to 4 visits spanning no longer than 4 months with a 1-month baseline period and up to 3-months open-label period. Compensation may be provided for time and travel.

    Duration: 4 Months

    Number: 4

    Migraine Research Study

    STS101-002

    Clinvest is seeking volunteers with migraine. This study is evaluating the safety and effectiveness of STS101, a dihydroergotamine (DHE) dry powder formulation in a single-use nasal device that is being developed for the treatment of migraine. Qualified volunteers will treat one migraine attack and be randomly assigned to receive a device containing a single dose of study medication STS101 in one of two different doses or a matching placebo. The total duration of the study will be last up to approximately 12 weeks. Your first appointment would last approximately 2 hours with follow-up visits lasting around 1 hour. Study medication would be provided, as well as all study-related procedures, at no cost to you (including basic study-related physical exams, bloodwork, ECG’s, and urine drug/pregnancy tests). Compensation will be provided for your time and travel.

    Duration: 12 Weeks

    Number: 2+

    Episodic Research Study

    3101-301-002

    Dr. True and Clinvest are seeking volunteers with Episodic Migraines in the Springfield area. The purpose of this research study is to evaluate the safety and efficacy of the investigational drug, Atogepant. Qualified volunteers, who have previously taken an oral migraine preventative medication, will be randomly assigned to receive investigational drug or Placebo. Completion of the study would involve coming into the office for 8 appointments over a 16-week period. Your first appointment will last approximately 2 hours. You will be asked to come into the office 4 weeks following screening and every 2 weeks for the duration of the 16-week study. A safety follow-up visit will occur 4 weeks after your last dose. At the completion of the study, participants will have the option to continue in a 40 week Open-Label study where active medication will be provided.

    Duration: 20 Weeks

    Number: 8

    Migraine Study

    GM-US-10

    This study consists of 5 in-person visits and 1 phone call over 16 weeks. Qualified people who report 8-20 headaches per month will be randomized to use non-invasive vagus nerve stimulation delivered through an investigational device 3 times a day during a 12-week treatment phase.  Your first appointment would last approximately 2 hours. If you qualify and choose to volunteer, we would provide the study device and all study-related procedures at no cost to you. You would be asked to use an electronic diary to answer daily questions about your headaches for the entire duration of the study. You would also be asked to fill out more detailed questionnaires during the appointments. Compensation will be provided for your time and travel.

    Duration: 16 Weeks

    Number: 5

    Post Traumatic Headaches

    TV48125-CNS-20024

    This research study is to compare the duration, safety, and effectiveness of the investigational study medication (Fremanezumab) to placebo (an inactive look-alike). Qualified volunteers will be randomly assigned to receive study medication or placebo. Completion of the study would involve coming to our office for 7 appointments, over a 44-week period. Subjects will receive 3 doses of investigational product or placebo during the study.

    Duration: 32 Weeks

    Number: 8

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